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DRUG RECORD

 

CHAMOMILE

(MATRICARIA RECUTITA)

OVERVIEW
Chamomile

 

Introduction

Chamomile is an aromatic oil extracted from the flowers or leaves of the daisy-like plants including German chamomile (Matricaria recutita) and Roman or English chamomile (Chamaemelum nobile).  Extracts, oils and teas made from chamomile are used for its soothing qualities as a sedative, mild analgesic and sleep medication.  Chamomile has not been implicated in causing serum enzyme elevations or clinically apparent liver injury.

 

Background

Chamomile (kam' o myle) is the common name for several daisy-like plants, the flowering tops of which are used to make teas, liquid extracts, capsules or tablets.  The chamomile most commonly used for its hypnotic and sedative effects is German chamomile (Matricaria recutita).  Chamomile extracts contain volatile oils, flavonoids and hydroxycoumarins.  The flavonoid apeginin has benzodiazepine-like activity and is believed to be the active component of the herbal.  Chamomile has multiple biologic effects in vitro and in vivo, including antiinflammatory, antioxidant, analgesic and sedative effects.  In humans, chamomile has been claimed to induce relaxation and sedation and has been used to treat nervousness and insomnia.  It is also used for cough, bronchitis, fever, wounds, mouth ulcers, burns, circulatory disorders, dyspepsia, depression and hair loss.  Chamomile oils are commonly used in aromatherapy and are found in many skin lotions, creams, soaps and cosmetics.  Chamomile is most often used as an herbal tea, but can also be inhaled, applied topically, or taken orally as tablets or capsules usually in combination with other herbals such as passionflower, aloe or valerian or with mild analgesics or antihistamines.  Chamomile has not been approved for use in any medical condition in the United States, but it is found in several hundred over-the-counter preparations.  Side effects are uncommon may include nausea, dizziness and allergic reactions.

 

Hepatotoxicity

Despite widescale use, chamomile has not been convincingly linked to instances of clinically apparent liver injury.

 

Other Names:  German Chamomile, Blue Chamomile, Wild Chamomile, True Chamomile, Manzanilla, Matricaire.

 

Drug Class:  Herbal and Dietary Supplements

See also Drug Class:  Sedatives and Hypnotics, Herbals

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REPRESENTATIVE TRADE NAMES
Chamomile – Generic (OTC Products)

 

DRUG CLASS
Herbal and Dietary Supplements
Sedatives and Hypnotics

 

COMPLETE LABELING

Product labeling at DailyMed, National Library of Medicine, NIH

 

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DRUG CAS REGISTRY NUMBER MOLECULAR FORMULA STRUCTURE
Chamomile 8002-66-2 Unspecified No Structure

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References updated: 23 January 2017

 

  1. Zimmerman HJ. Unconventional drugs. Miscellaneous drugs and diagnostic chemicals. In, Zimmerman HJ. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. 2nd ed. Philadelphia: Lippincott, 1999, pp. 731-4.  (Expert review of hepatotoxicity published in 1999; several herbals are discussed, including comfrey, Jin Bu huan, germander, chaparral leaf, skullcap and valerian, but not chamomile).

  2. Seeff L, Stickel F, Navarro VJ. Hepatotoxicity of herbals and dietary supplements. In, Kaplowitz N, DeLeve LD, eds. Drug-induced liver disease. 3rd ed. Amsterdam: Elsevier, 2013, pp. 631-58.  (Review of hepatotoxicity of herbal and dietary supplements [HDS]; chamomile is not discussed).

  3. German Chamomile. In, PDR for Herbal Medicines. 4th ed. Montvale, New Jersey: Thomson Healthcare Inc., 2007: pp. 357-62.  (Compilation of short monographs on herbal medications and dietary supplements).

  4. Gyllenhaal C, Merritt SL, Peterson SD, Block KI, Gochenour T. Efficacy and safety of herbal stimulants and sedatives in sleep disorders. Sleep Med Rev 2000; 4: 229-251. PubMed Citation  (Review of herbals used for sleep disorders; mentions that the sedative effects of chamomile are mild, but that clinical studies are lacking and allergic reactions to it have been reported).

  5. Wheatley D. Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability. J Psychopharmacol 2005; 19: 414-21. PubMed Citation  (Review of herbals used to treat insomnia; mentions that chamomile is widely regarded as a mild tranquillizer and sleep inducer; no mention of side effects).

  6. Meolie AL, Rosen C, Kristo D, Kohrman M, Gooneratne N, Aguillard RN, Fayle R, et al.; Clinical Practice Review Committee; American Academy of Sleep Medicine. Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence. J Clin Sleep Med 2005; 1: 173-87. PubMed Citation  (Systematic review of efficacy of nonprescription treatments for insomnia states that German chamomile is used for restlessness and insomnia, but clinical studies of its efficacy are lacking and its side effects may include vomiting, allergic reactions and drug-herb interactions).

  7. Sarris J, Panossian A, Schweitzer I, Stough C, Scholey A. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. Eur Neuropsychopharmacol 2011; 21: 841-60. PubMed Citation  (Overview and summary of herbals used to treat anxiety, depression and insomnia; ranks chamomile as having evidence level "B" for efficacy in anxiety in humans).

  8. Drugs for insomnia. Treat Guidel Med Lett 2012; 10 (119): 57-60. PubMed Citation  (Guidelines for therapy of insomnia; mentions herbal products that are claimed to have sleep inducing effects including valerian root, kava, chamomile tea, passionflower, hops, lemon balm, lavender and skull cap, but that there is no convincing evidence for their efficacy and that the purity of commercially available over-the-counter products is suspect).

  9. Navarro VJ, Barnhart H, Bonkovsky HL, Davern T, Fontana RJ, Grant L, Reddy KR, et al. Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network. Hepatology 2014; 60:1399-408. PubMed Citation  (Among 85 cases of HDS associated liver injury [not due to anabolic steroids] enrolled in a US prospective study between 2004 and 2013, none were attributed to chamomile).

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OTHER REFERENCE LINKS
Chamomile

 

  1. PubMed logoRecent References on Chamomile

  2. Clinical Trials logoTrials on Chamomile

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